ST7

Across TCGA patient cohorts, ST7 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST7-associated genes across cancer lineages are Notch1, ATM, and p62 Lck ligand. Each is linked with ST7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST7-to-partner and partner-to-ST7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ST7-low versus ST7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST7→partner) and Y-score (partner→ST7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.146	+2.000	.003	.003	3	3
UCEC	ATM →	-0.564	-2.571	<.001	.010	3	3
LUSC	p62 Lck ligand →	+0.704	+2.816	.027	.036	3	2
LUSC	Caspase-7-cleavedD198 →	+0.787	+2.816	.004	.036	3	2
SKCM	GAPDH →	+0.708	+3.000	.035	.036	3	2
SKCM	PKC-delta_pS664 →	+0.219	+3.000	.041	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Notch1 by ST7 expression — UCEC

Explore this box plot interactively →