Across TCGA pan-cancer cohorts, ST6GALNAC3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ST6GALNAC3 data layer compared with 6 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ST6GALNAC3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ST6GALNAC3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.
KIRC, UVM, and BLCA are the cancer types where ST6GALNAC3 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.