ST6GAL2

Across TCGA patient cohorts, ST6GAL2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST6GAL2-associated genes across cancer lineages are ASNS, FASN, and 4E-BP1. Each is linked with ST6GAL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST6GAL2-to-partner and partner-to-ST6GAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ST6GAL2-low versus ST6GAL2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GAL2→partner) and Y-score (partner→ST6GAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.448	+1.700	.017	.043	3	3
COAD	FASN →	+0.546	+3.330	.002	.005	3	3
COAD	4E-BP1 →	+0.254	+2.178	.013	.035	3	3
COAD	JNK_pT183_Y185 →	-0.302	-3.313	.013	.010	3	2
LUAD	MSH2 →	+0.245	+3.169	.027	.018	3	2
LUAD	cIAP →	+0.101	+3.182	.029	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ASNS by ST6GAL2 expression — LUAD

Explore this box plot interactively →