ST6GAL1

Across TCGA patient cohorts, ST6GAL1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST6GAL1-associated genes across cancer lineages are FASN, GAPDH, and ACC1. Each is linked with ST6GAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST6GAL1-to-partner and partner-to-ST6GAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ST6GAL1-low versus ST6GAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GAL1→partner) and Y-score (partner→ST6GAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.335	+2.321	.023	.033	3	2
UCEC	GAPDH →	+0.539	+1.700	.007	.042	3	2
UCEC	ACC1 →	+0.269	+2.335	.049	.018	3	2
UCEC	PCNA →	+0.257	+2.662	.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.421	-2.807	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.819	+2.584	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FASN by ST6GAL1 expression — UCEC

Explore this box plot interactively →