ST6GAL1

Across TCGA cell cohorts, ST6GAL1 mutation is significantly associated with the mutation status of many other genes, with 1,086 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ST6GAL1-associated genes across cancer lineages are GABRG1, PTGS2, and TSPAN17. Each is linked with ST6GAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST6GAL1-to-partner and partner-to-ST6GAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRG1 grouped by ST6GAL1-low versus ST6GAL1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GAL1→partner) and Y-score (partner→ST6GAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GABRG1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	PTGS2 →	+5.014	+5.584	.003	.003	1	2
LARGE_INTESTINE	TSPAN17 →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	CX3CL1 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	AP3M2 →	+5.087	+4.523	.006	.006	1	2
UPPER_AERODIGESTIVE_TRACT	DNMBP →	+5.392	+5.392	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,086 associations by consensus.

GABRG1 by ST6GAL1 expression — BLOOD_Lymphoma

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