ST3GAL6

Across TCGA pan-cancer cohorts, ST3GAL6 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ST3GAL6 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ST3GAL6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ST3GAL6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ACC show a favorable association.

BLCA, STAD, and LUAD are the cancer types where ST3GAL6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.334	0.533	<.001	103	view →
STAD	OS	Tertile	All	0.461	0.654	<.001	95	view →
LUAD	OS	Median	All	0.432	0.283	.002	32	view →
ACC	OS	Median	II,III,IV	0.916	0.642	.009	30	view →
LAML	DFS	Quartile	All	0.748	0.268	.001	30	view →
LIHC	OS	Tertile	III,IV	0.833	0.586	.010	26	view →
MESO	OS	Quartile	III,IV	0.539	0.235	.002	24	view →
SKCM	OS	Quartile	All	0.571	0.246	.003	23	view →
LUSC	OS	Median	III,IV	0.512	0.935	.003	22	view →
DLBC	DFS	Quartile	II,III,IV	0.971	0.532	.017	16	view →
SCLC	DFS	Tertile	All	0.767	0.335	.014	6	view →
TGCT	DFS	Quartile	All	0.524	0.824	.030	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ST3GAL6–BLCA (OS)

Open the BLCA breakdown →