ST3GAL4

Across TCGA pan-cancer cohorts, ST3GAL4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ST3GAL4 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ST3GAL4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ST3GAL4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where ST3GAL4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.854	0.350	.022	6	view →
LSCC	DFS	Tertile	II,III,IV	0.532	0.852	.022	5	view →
PDAC	OS	Median	All	0.375	0.625	.014	5	view →
GBM	DFS	Median	All	0.568	0.190	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ST3GAL4–HNSC (DFS)

Open the HNSC breakdown →