ST3GAL3

Across TCGA patient cohorts, ST3GAL3 mutation is significantly associated with the RNA expression of many other genes, with 2,318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST3GAL3-associated genes across cancer lineages are RNA5SP413, MIR6894, and IGHD1-1. Each is linked with ST3GAL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ST3GAL3-to-partner and partner-to-ST3GAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by ST3GAL3-low versus ST3GAL3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST3GAL3→partner) and Y-score (partner→ST3GAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP413 →	+2.340	+6.081	<.001	.002	3	4
BRCA	MIR6894 →	+0.402	+4.506	<.001	.009	3	3
UCEC	IGHD1-1 →	+0.474	+3.013	<.001	<.001	3	3
LUSC	RNA5SP419 →	+1.388	+7.102	<.001	<.001	3	3
LUSC	RNA5SP417 →	+1.676	+5.882	<.001	.002	3	3
LUSC	RNA5SP422 →	+1.505	+6.733	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,318 associations by consensus.

RNA5SP413 by ST3GAL3 expression — LUSC

Explore this box plot interactively →