ST3GAL3

Across TCGA cell cohorts, ST3GAL3 mutation is significantly associated with the RNA expression of many other genes, with 124 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ST3GAL3-associated genes across cancer lineages are NKX2-6, TLE7, and GCAT. Each is linked with ST3GAL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST3GAL3-to-partner and partner-to-ST3GAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by ST3GAL3-low versus ST3GAL3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST3GAL3→partner) and Y-score (partner→ST3GAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	GCAT →	+1.178	+3.364	.003	.002	3	1
LARGE_INTESTINE	ST8SIA5 →	+0.228	+2.647	.005	.005	3	1
LARGE_INTESTINE	ELOB →	-0.517	-3.192	.001	.006	3	1
LARGE_INTESTINE	LILRA1 →	+0.008	+2.247	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 124 associations by consensus.

NKX2-6 by ST3GAL3 expression — BLOOD_Leukemia

Explore this box plot interactively →