ST3GAL2

Across TCGA patient cohorts, ST3GAL2 mutation is significantly associated with the RNA expression of many other genes, with 594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST3GAL2-associated genes across cancer lineages are TRBV17, PLEKHG4B, and CD8A. Each is linked with ST3GAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST3GAL2-to-partner and partner-to-ST3GAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRBV17 grouped by ST3GAL2-low versus ST3GAL2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST3GAL2→partner) and Y-score (partner→ST3GAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRBV17 →	+0.136	+5.721	<.001	.003	3	1
UCEC	PLEKHG4B →	-1.094	-2.796	<.001	.003	3	1
UCEC	CD8A →	+1.452	+3.928	<.001	<.001	3	1
UCEC	ZDHHC7 →	+0.514	+3.483	<.001	.002	3	1
UCEC	LRRK1 →	-0.666	-3.692	<.001	.001	3	1
UCEC	GBP5 →	+1.381	+2.818	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 594 associations by consensus.

TRBV17 by ST3GAL2 expression — BRCA

Explore this box plot interactively →