ST3GAL2

Across TCGA patient cohorts, ST3GAL2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST3GAL2-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and GATA6. Each is linked with ST3GAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST3GAL2-to-partner and partner-to-ST3GAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by ST3GAL2-low versus ST3GAL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST3GAL2→partner) and Y-score (partner→ST3GAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.126	-2.999	.030	.035	3	1
UCEC	GAPDH →	+0.634	+2.999	.011	.035	3	1
UCEC	GATA6 →	-0.150	-3.000	.037	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-2.321	.017	.034	3	1
UCEC	Ku80 →	+0.352	+3.713	.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.198	-3.302	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FOXO3a_pS318_S321 by ST3GAL2 expression — UCEC

Explore this box plot interactively →