ST3GAL1

Across TCGA patient cohorts, ST3GAL1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST3GAL1-associated genes across cancer lineages are PDCD4, TFRC, and Notch1. Each is linked with ST3GAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST3GAL1-to-partner and partner-to-ST3GAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ST3GAL1-low versus ST3GAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST3GAL1→partner) and Y-score (partner→ST3GAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.452	-1.690	.012	.042	3	2
UCEC	TFRC →	+0.553	+2.459	.006	.018	3	2
UCEC	Notch1 →	+0.161	+1.678	.002	.023	3	2
UCEC	ATM →	-0.479	-3.446	.005	.005	3	2
UCEC	4E-BP1_pT37_T46 →	-0.296	-3.156	.039	.018	3	2
UCEC	4E-BP1 →	+0.237	+2.145	.022	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PDCD4 by ST3GAL1 expression — UCEC

Explore this box plot interactively →