ST20

Across TCGA pan-cancer cohorts, ST20 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ST20 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ST20 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ST20 expression acts as an unfavorable survival marker, although some lineages such as CHOL and ESCA show a favorable association.

UVM, ACC, and KIRC are the cancer types where ST20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	III,IV	0.281	0.932	<.001	109	view →
ACC	OS	Tertile	All	0.443	0.869	<.001	108	view →
KIRC	DFS	Quartile	IV	0.341	0.784	<.001	62	view →
KIRP	DFS	Median	All	0.470	0.692	<.001	60	view →
BRCA	DFS	Quartile	II,III,IV	0.827	0.918	.003	58	view →
LGG	DFS	Median	All	0.603	0.861	<.001	54	view →
CHOL	OS	Median	All	0.784	0.284	.010	24	view →
MESO	OS	Quartile	II,III,IV	0.205	0.508	.013	21	view →
PRAD	DFS	Median	All	0.678	0.901	<.001	18	view →
KICH	DFS	Median	All	0.750	1.000	.016	16	view →
LIHC	DFS	Tertile	All	0.457	0.624	.007	14	view →
STAD	DFS	Tertile	IV	0.252	0.740	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ST20–UVM (OS)

Open the UVM breakdown →