Across TCGA pan-cancer cohorts, SSX7 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of SSX7’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where SSX7 RNA is repressed in tumor relative to normal tissue. In most cancer types SSX7 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where SSX7 tumor–normal differential expression is most reproducible.