SSX2IP

Across TCGA patient cohorts, SSX2IP mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSX2IP-associated genes across cancer lineages are 14-3-3_beta, JNK2, and STAT3_pY705. Each is linked with SSX2IP in more than 1 cancer types. Because this analysis shows association rather than direction, both SSX2IP-to-partner and partner-to-SSX2IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SSX2IP-low versus SSX2IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSX2IP→partner) and Y-score (partner→SSX2IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.070	-2.673	.020	.005	3	2
UCEC	JNK2 →	+0.228	+1.807	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.353	-1.736	<.001	.005	3	2
UCEC	ATM →	-0.685	-2.632	<.001	<.001	3	2
UCEC	eEF2 →	+0.269	+1.906	.011	.014	3	1
UCEC	EGFR_pY1068 →	-0.280	-1.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

14-3-3_beta by SSX2IP expression — UCEC

Explore this box plot interactively →