SSX2

Across TCGA patient cohorts, SSX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,075 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SSX2-associated GO terms across cancer lineages are Positive regulation of double-strand break repair via nonhomologous end joining, Protein methylation, and Microtubule-based transport. Each is linked with SSX2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SSX2-to-partner and partner-to-SSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair via nonhomologous end joining grouped by SSX2-low versus SSX2-high in HNSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSX2→partner) and Y-score (partner→SSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Positive regulation of double-strand break repair via nonhomologous end joining →	+0.055	+0.002	<.001	.001	3	7
STAD	Protein methylation →	+0.052	+0.092	<.001	<.001	3	7
STAD	Microtubule-based transport →	+0.036	+0.063	<.001	.005	3	6
THYM	Regulation of protein folding →	+0.080	+0.036	<.001	<.001	3	6
THYM	Protein localization to ciliary membrane →	+0.055	+0.020	.001	<.001	3	6
STAD	Internal protein amino acid acetylation →	+0.060	+0.053	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,075 associations by consensus.

Positive regulation of double-strand break repair via nonhomologous end joining by SSX2 expression — HNSC

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