SSX1

Across TCGA cell cohorts, SSX1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SSX1-associated genes across cancer lineages are KCNA4, KRTAP21-2, and CASP12. Each is linked with SSX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSX1-to-partner and partner-to-SSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA4 grouped by SSX1-low versus SSX1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSX1→partner) and Y-score (partner→SSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KCNA4 →	+0.141	+4.199	<.001	.007	3	1
BREAST	KRTAP21-2 →	+0.457	+4.199	<.001	.007	3	1
BREAST	CASP12 →	+0.024	+4.963	.004	.001	3	1
BREAST	HIGD1C →	+0.112	+4.672	.003	.002	3	1
BREAST	CT45A7 →	+0.185	+4.963	<.001	.001	3	1
BREAST	CCL18 →	+0.048	+4.672	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KCNA4 by SSX1 expression — BREAST

Explore this box plot interactively →