SSU72P8

Across TCGA patient cohorts, SSU72P8 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSU72P8-associated genes across cancer lineages are 14-3-3_zeta, p27, and p38-MAPK_pT180_Y182. Each is linked with SSU72P8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSU72P8-to-partner and partner-to-SSU72P8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_zeta grouped by SSU72P8-low versus SSU72P8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSU72P8→partner) and Y-score (partner→SSU72P8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	14-3-3_zeta →	+0.419	+2.853	.023	.034	3	1
UCEC	p27 →	-0.219	-2.321	.046	.035	2	2
UCEC	p38-MAPK_pT180_Y182 →	-0.620	-3.169	.006	.019	3	1
UCEC	TFRC →	+0.558	+2.321	.036	.035	3	1
UCEC	TSC1 →	-0.206	-2.321	.016	.035	3	1
UCEC	Bax →	+0.248	+2.321	.039	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_zeta by SSU72P8 expression — LUSC

Explore this box plot interactively →