SSTR4

Across TCGA pan-cancer cohorts, SSTR4 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated SSTR4 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SSTR4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SSTR4 expression acts as an unfavorable survival marker.

THYM, BLCA, and DLBC are the cancer types where SSTR4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	OS	Median	All	0.069	0.688	<.001	18	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
CESC	OS	Median	IV	0.121	0.591	.029	12	view →
LUSC	DFS	Median	III,IV	0.155	0.663	.002	12	view →
CHOL	OS	Median	All	0.154	0.793	.004	9	view →
LUAD	OS	Median	All	0.317	0.679	.002	7	view →
PRAD	DFS	Median	All	0.617	0.886	.020	6	view →
SKCM	OS	Median	III,IV	0.366	0.709	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SSTR4–THYM (OS)

Open the THYM breakdown →