SSTR4

Across TCGA cell cohorts, SSTR4 mutation is significantly associated with the mutation status of many other genes, with 4,434 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SSTR4-associated genes across cancer lineages are USP42, MAST4, and NAT10. Each is linked with SSTR4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SSTR4-to-partner and partner-to-SSTR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP42 grouped by SSTR4-low versus SSTR4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSTR4→partner) and Y-score (partner→SSTR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	USP42 →	+3.240	+4.467	.004	.004	1	5
OVARY	MAST4 →	+3.240	+4.467	.004	.004	1	4
OVARY	NAT10 →	+4.977	+4.415	.007	.007	1	4
CNS	SZT2 →	+3.614	+4.954	.001	.001	1	4
OVARY	LYST →	+2.977	+4.273	.006	.006	1	4
BLOOD_Leukemia	POLR3A →	+3.309	+4.794	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,434 associations by consensus.

USP42 by SSTR4 expression — OVARY

Explore this box plot interactively →