SSTR3

Across TCGA patient cohorts, SSTR3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSTR3-associated genes across cancer lineages are A-Raf_pS299, MSH6, and 14-3-3_beta. Each is linked with SSTR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSTR3-to-partner and partner-to-SSTR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SSTR3-low versus SSTR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSTR3→partner) and Y-score (partner→SSTR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.165	-2.502	<.001	.002	3	2
UCEC	MSH6 →	-0.646	-3.896	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.125	-3.432	.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.310	-1.584	.001	.036	3	1
UCEC	ERK2 →	+0.197	+2.000	.009	.010	3	1
UCEC	ACC1 →	+0.311	+2.183	.029	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

A-Raf_pS299 by SSTR3 expression — UCEC

Explore this box plot interactively →