SSTR1

Across TCGA patient cohorts, SSTR1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSTR1-associated genes across cancer lineages are Notch1, ATM, and Caspase-7-cleavedD198. Each is linked with SSTR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SSTR1-to-partner and partner-to-SSTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SSTR1-low versus SSTR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSTR1→partner) and Y-score (partner→SSTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.108	+1.106	.006	.020	3	3
COAD	ATM →	-0.590	-2.576	<.001	.011	3	3
COAD	Caspase-7-cleavedD198 →	+1.258	+3.321	<.001	.009	3	3
UCEC	4E-BP1 →	+0.304	+2.100	<.001	<.001	3	3
COAD	eEF2 →	+0.362	+1.882	.003	.031	3	2
COAD	eIF4E →	+0.175	+3.182	.019	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Notch1 by SSTR1 expression — UCEC

Explore this box plot interactively →