SST

Across TCGA patient cohorts, SST mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SST-associated genes across cancer lineages are RNA5SP158, RPL7AP23, and RNA5SP71. Each is linked with SST in more than 1 cancer types. Because this analysis shows association rather than direction, both SST-to-partner and partner-to-SST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP158 grouped by SST-low versus SST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SST→partner) and Y-score (partner→SST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP158 →	+0.304	+5.049	<.001	.002	3	2
SKCM	RPL7AP23 →	+0.050	+3.993	.001	.005	3	2
LUSC	RNA5SP71 →	+0.709	+5.337	<.001	.006	3	2
UCEC	IGKV2OR2-2 →	+0.196	+3.759	.001	.005	3	1
UCEC	RNA5SP411 →	+1.818	+3.393	<.001	.007	3	1
UCEC	MIR6894 →	+0.845	+3.496	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

RNA5SP158 by SST expression — UCEC

Explore this box plot interactively →