SST

Across TCGA cell cohorts, SST RNA expression is significantly associated with the go_rna of many other GO terms, with 845 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SST-associated GO terms across cancer lineages are Hormone-mediated apoptotic signaling pathway, Lysosomal lumen acidification, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with SST in more than 9 cancer types. Because this analysis shows association rather than direction, both SST-to-partner and partner-to-SST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hormone-mediated apoptotic signaling pathway grouped by SST-low versus SST-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SST→partner) and Y-score (partner→SST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Hormone-mediated apoptotic signaling pathway →	+1.415	+3.858	<.001	<.001	3	10
OVARY	Lysosomal lumen acidification →	+0.093	+1.853	.001	.007	3	5
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.080	+1.508	.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of vacuole organization →	+0.051	+0.082	.008	.006	3	4
BLOOD_Myeloma	Sensory perception of light stimulus →	-0.037	-0.120	<.001	.001	3	4
BLOOD_Leukemia	Positive regulation of pinocytosis →	+0.087	+0.112	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 845 associations by consensus.

Hormone-mediated apoptotic signaling pathway by SST expression — LUNG_SCLC

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