SSRP1

Across TCGA patient cohorts, SSRP1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSRP1-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and ATM. Each is linked with SSRP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SSRP1-to-partner and partner-to-SSRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SSRP1-low versus SSRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSRP1→partner) and Y-score (partner→SSRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.592	+1.906	.004	.014	3	3
UCEC	ASNS →	+0.463	+2.700	<.001	.005	3	2
UCEC	ATM →	-0.592	-2.000	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.103	-2.673	.003	.005	3	1
UCEC	eEF2 →	+0.354	+3.459	.005	.005	3	1
UCEC	EGFR_pY1068 →	-0.248	-2.584	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by SSRP1 expression — UCEC

Explore this box plot interactively →