SSR4

Across TCGA patient cohorts, SSR4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSR4-associated genes across cancer lineages are EGFR_pY1068, ERK2, and MAPK_pT202_Y204. Each is linked with SSR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSR4-to-partner and partner-to-SSR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SSR4-low versus SSR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSR4→partner) and Y-score (partner→SSR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.222	-2.115	.043	.019	3	1
UCEC	ERK2 →	+0.236	+3.906	.005	<.001	3	1
UCEC	MAPK_pT202_Y204 →	-0.514	-3.156	.012	.018	3	1
UCEC	mTOR_pS2448 →	-0.135	-2.986	.038	.035	3	1
UCEC	eEF2 →	+0.320	+3.000	.040	.036	2	1
UCEC	Shc_pY317 →	-0.189	-3.584	.004	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by SSR4 expression — UCEC

Explore this box plot interactively →