SSR4

Across TCGA cell cohorts, SSR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,206 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SSR4-associated GO terms across cancer lineages are Natural killer cell degranulation, Protein import into nucleus, and Pyruvate import into mitochondria. Each is linked with SSR4 in more than 9 cancer types. Because this analysis shows association rather than direction, both SSR4-to-partner and partner-to-SSR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Natural killer cell degranulation grouped by SSR4-low versus SSR4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSR4→partner) and Y-score (partner→SSR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Natural killer cell degranulation →	+0.295	+0.938	.002	.007	3	10
BLOOD_Leukemia	Protein import into nucleus →	-0.045	-0.477	<.001	<.001	3	10
SOFT_TISSUE	Pyruvate import into mitochondria →	+0.130	+0.975	.001	<.001	3	9
SOFT_TISSUE	Regulation of transcription by RNA polymerase I →	-0.080	-0.729	<.001	<.001	3	9
SOFT_TISSUE	Host-mediated perturbation of viral transcription →	-0.094	-0.734	<.001	<.001	3	9
SKIN	Positive regulation of cell cycle →	-0.059	-0.609	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,206 associations by consensus.

Natural killer cell degranulation by SSR4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →