SSR3

Across TCGA patient cohorts, SSR3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSR3-associated genes across cancer lineages are FOXO3a_pS318_S321, STAT3_pY705, and TIGAR. Each is linked with SSR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSR3-to-partner and partner-to-SSR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by SSR3-low versus SSR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSR3→partner) and Y-score (partner→SSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.147	-2.990	.041	.036	3	1
UCEC	STAT3_pY705 →	-0.430	-3.000	.004	.037	3	1
UCEC	TIGAR →	+0.311	+3.026	<.001	.019	3	1
UCEC	VEGFR2 →	+0.377	+2.817	.028	.036	3	1
UCEC	p70-S6K_pT389 →	-0.221	-3.000	.044	.037	2	1
UCEC	p90 RSK_pT359_S363 →	-0.264	-3.000	.023	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FOXO3a_pS318_S321 by SSR3 expression — UCEC

Explore this box plot interactively →