SSR3

Across TCGA cell cohorts, SSR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,182 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SSR3-associated GO terms across cancer lineages are Regulation of protein exit from endoplasmic reticulum, Positive regulation of protein exit from endoplasmic reticulum, and SRP-dependent cotranslational protein targeting to membrane. Each is linked with SSR3 in more than 11 cancer types. Because this analysis shows association rather than direction, both SSR3-to-partner and partner-to-SSR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein exit from endoplasmic reticulum grouped by SSR3-low versus SSR3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSR3→partner) and Y-score (partner→SSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of protein exit from endoplasmic reticulum →	+0.120	+0.981	.001	.003	3	12
KIDNEY	Positive regulation of protein exit from endoplasmic reticulum →	+0.129	+1.215	<.001	<.001	3	12
SOFT_TISSUE	SRP-dependent cotranslational protein targeting to membrane →	+0.106	+0.908	<.001	.001	3	11
BLOOD_Myeloma	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.108	+0.872	.006	.007	3	10
BLOOD_Myeloma	Cotranslational protein targeting to membrane →	+0.140	+1.235	<.001	<.001	3	10
SOFT_TISSUE	IRE1-mediated unfolded protein response →	+0.123	+0.907	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,182 associations by consensus.

Regulation of protein exit from endoplasmic reticulum by SSR3 expression — STOMACH

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