SSR2

Across TCGA cell cohorts, SSR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,135 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SSR2-associated GO terms across cancer lineages are Positive regulation of protein exit from endoplasmic reticulum, Protein demannosylation, and Protein alpha-1,2-demannosylation. Each is linked with SSR2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SSR2-to-partner and partner-to-SSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein exit from endoplasmic reticulum grouped by SSR2-low versus SSR2-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSR2→partner) and Y-score (partner→SSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of protein exit from endoplasmic reticulum →	+0.103	+0.537	<.001	.001	2	11
SOFT_TISSUE	Protein demannosylation →	+0.088	+0.524	<.001	.003	3	9
SOFT_TISSUE	Protein alpha-1,2-demannosylation →	+0.088	+0.524	<.001	.003	3	9
BONE	COPII-coated vesicle cargo loading →	+0.114	+0.679	<.001	.007	3	9
BLOOD_Myeloma	ERAD pathway →	+0.085	+1.241	.006	.002	3	8
BLOOD_Myeloma	Endoplasmic reticulum unfolded protein response →	+0.127	+1.355	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,135 associations by consensus.

Positive regulation of protein exit from endoplasmic reticulum by SSR2 expression — CNS

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