SSR1

Across TCGA patient cohorts, SSR1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSR1-associated genes across cancer lineages are 14-3-3_beta, JNK2, and MEK1. Each is linked with SSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSR1-to-partner and partner-to-SSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SSR1-low versus SSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSR1→partner) and Y-score (partner→SSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.134	-3.143	.004	.018	3	1
UCEC	JNK2 →	+0.269	+2.584	.003	.011	3	1
UCEC	MEK1 →	+0.484	+3.459	.004	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.228	+3.713	.018	<.001	3	1
UCEC	Myosin-IIa →	+0.200	+3.180	.020	.010	3	1
UCEC	p27_pT157 →	-0.069	-2.986	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

14-3-3_beta by SSR1 expression — UCEC

Explore this box plot interactively →