SSPN

Across TCGA pan-cancer cohorts, SSPN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SSPN data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SSPN RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SSPN expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

SKCM, UCS, and ACC are the cancer types where SSPN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Quartile	All	0.693	0.542	<.001	66	view →
UCS	DFS	Tertile	II,III,IV	0.477	0.140	.010	48	view →
ACC	OS	Quartile	II,III,IV	0.325	0.786	.009	37	view →
LUSC	DFS	Median	II,III,IV	0.301	0.505	.002	31	view →
DLBC	OS	Median	All	1.000	0.482	.011	27	view →
CHOL	OS	Median	II,III,IV	0.800	0.347	.032	14	view →
PAAD	OS	Quartile	All	0.277	0.622	.005	14	view →
PRAD	DFS	Median	All	0.864	0.708	.006	12	view →
KIRC	DFS	Quartile	All	0.885	0.724	.013	10	view →
THCA	DFS	Quartile	IV	1.000	0.476	.021	9	view →
MESO	DFS	Median	All	0.223	0.622	.002	9	view →
BRCA	DFS	Quartile	III,IV	0.594	0.456	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SSPN–SKCM (DFS)

Open the SKCM breakdown →