Across TCGA pan-cancer cohorts, SSNA1 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of SSNA1’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where SSNA1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SSNA1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
COAD are the cancer types where SSNA1 tumor–normal differential expression is most reproducible.