SSH2

Across TCGA cell cohorts, SSH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,603 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SSH2-associated GO terms across cancer lineages are Negative regulation of actin filament polymerization, Cytoskeleton-dependent cytokinesis, and Regulation of centriole-centriole cohesion. Each is linked with SSH2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SSH2-to-partner and partner-to-SSH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin filament polymerization grouped by SSH2-low versus SSH2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSH2→partner) and Y-score (partner→SSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of actin filament polymerization →	+0.130	+1.158	.004	.001	3	9
OESOPHAGUS	Cytoskeleton-dependent cytokinesis →	+0.090	+0.883	.002	<.001	3	9
SOFT_TISSUE	Regulation of centriole-centriole cohesion →	+0.101	+0.678	<.001	<.001	3	9
SOFT_TISSUE	Protein localization to microtubule cytoskeleton →	+0.065	+0.967	.003	<.001	3	9
KIDNEY	Negative regulation of protein oligomerization →	+0.131	+1.125	.003	.001	3	8
OESOPHAGUS	Cytokinesis →	+0.090	+0.883	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,603 associations by consensus.

Negative regulation of actin filament polymerization by SSH2 expression — KIDNEY

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