SSH2

Across TCGA cell cohorts, SSH2 mutation is significantly associated with the RNA expression of many other genes, with 344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SSH2-associated genes across cancer lineages are DPRX, CD1C, and LRRC3C. Each is linked with SSH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSH2-to-partner and partner-to-SSH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by SSH2-low versus SSH2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSH2→partner) and Y-score (partner→SSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DPRX →	+0.039	+3.906	<.001	.001	3	2
LUNG_NSCLC_LUAD	CD1C →	+0.021	+3.043	<.001	.006	3	2
BLOOD_Leukemia	LRRC3C →	+0.073	+4.090	<.001	<.001	3	2
BLOOD_Leukemia	APOC4 →	+0.155	+4.022	.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	OR11H6 →	+0.102	+3.917	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	OR52I2 →	+0.086	+3.722	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 344 associations by consensus.

DPRX by SSH2 expression — CNS

Explore this box plot interactively →