SSH1

Across TCGA pan-cancer cohorts, SSH1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SSH1 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SSH1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SSH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where SSH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.139	0.979	.001	68	view →
HNSC	DFS	Quartile	III,IV	1.000	0.845	.013	11	view →
PDAC	OS	Median	All	0.445	0.639	.007	8	view →
UCEC	DFS	Quartile	III,IV	1.000	0.419	.040	4	view →
GBM	OS	Median	All	0.443	0.613	.023	2	view →
LUAD	OS	Quartile	III,IV	0.189	0.742	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SSH1–CCRCC (DFS)

Open the CCRCC breakdown →