SSC4D

Across TCGA pan-cancer cohorts, SSC4D Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SSC4D data layer compared with 23 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SSC4D Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SSC4D expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

CESC, UCEC, and HNSC are the cancer types where SSC4D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.184	0.705	.036	12	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
HNSC	OS	Median	All	0.185	0.685	.036	9	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
BLCA	DFS	Median	IV	0.090	0.476	.011	6	view →
SKCM	DFS	Median	All	1.000	0.731	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SSC4D–CESC (DFS)

Open the CESC breakdown →