SSBP3

Across TCGA patient cohorts, SSBP3 mutation is significantly associated with the RNA expression of many other genes, with 2,001 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSBP3-associated genes across cancer lineages are ZNHIT3, TAF9, and CHEK1. Each is linked with SSBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSBP3-to-partner and partner-to-SSBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNHIT3 grouped by SSBP3-low versus SSBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSBP3→partner) and Y-score (partner→SSBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNHIT3 →	+0.456	+2.665	<.001	<.001	3	2
UCEC	TAF9 →	+0.661	+2.263	<.001	<.001	3	2
UCEC	CHEK1 →	+0.692	+4.021	<.001	<.001	3	2
COAD	PELO →	+0.405	+3.250	.002	.008	3	2
UCEC	RAD17 →	+0.464	+2.642	<.001	<.001	3	2
UCEC	CENPH →	+0.573	+2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,001 associations by consensus.

ZNHIT3 by SSBP3 expression — UCEC

Explore this box plot interactively →