SSBP3

Across TCGA patient cohorts, SSBP3 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSBP3-associated genes across cancer lineages are TFRC, EGFR_pY1068, and GAPDH. Each is linked with SSBP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SSBP3-to-partner and partner-to-SSBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SSBP3-low versus SSBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSBP3→partner) and Y-score (partner→SSBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.757	+2.000	<.001	.010	3	3
UCEC	EGFR_pY1068 →	-0.355	-4.247	<.001	<.001	3	2
UCEC	GAPDH →	+0.531	+3.321	.011	.009	3	2
COAD	Shc_pY317 →	-0.256	-2.991	.003	.036	3	2
UCEC	TIGAR →	+0.121	+1.611	.044	.022	3	2
UCEC	Caspase-7-cleavedD198 →	+0.730	+2.479	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

TFRC by SSBP3 expression — UCEC

Explore this box plot interactively →