SSBP2

Across TCGA pan-cancer cohorts, SSBP2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SSBP2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SSBP2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SSBP2 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and LUAD are the cancer types where SSBP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SSBP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−1.037	<.001	11	view →
CCRCC	All	All	−0.361	<.001	10	view →
LUAD	Male	II,III,IV	−0.588	<.001	8	view →
LSCC	All	All	−0.445	<.001	6	view →
COAD	All	All	−1.850	.038	2	view →
PDAC	Female	II,III,IV	−0.512	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SSBP2–HNSC

Open the HNSC breakdown →