SSBP1

Across TCGA patient cohorts, SSBP1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSBP1-associated genes across cancer lineages are eIF4E, ERK2, and MEK1. Each is linked with SSBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSBP1-to-partner and partner-to-SSBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SSBP1-low versus SSBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSBP1→partner) and Y-score (partner→SSBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.202	+2.459	.048	.020	3	1
UCEC	ERK2 →	+0.236	+3.169	.011	.018	3	1
UCEC	MEK1 →	+0.402	+3.169	.023	.019	3	1
UCEC	MSH6 →	-0.339	-2.999	.033	.035	3	1
UCEC	VHL →	-0.688	-3.321	.036	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.876	+3.341	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eIF4E by SSBP1 expression — UCEC

Explore this box plot interactively →