SS18L2

Across TCGA cell cohorts, SS18L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,985 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SS18L2-associated GO terms across cancer lineages are tRNA 3'-terminal CCA addition, Mitochondrial tRNA 3'-end processing, and Positive regulation of G2/MI transition of meiotic cell cycle. Each is linked with SS18L2 in more than 14 cancer types. Because this analysis shows association rather than direction, both SS18L2-to-partner and partner-to-SS18L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA 3'-terminal CCA addition grouped by SS18L2-low versus SS18L2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SS18L2→partner) and Y-score (partner→SS18L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	tRNA 3'-terminal CCA addition →	+0.164	+0.746	<.001	<.001	3	15
BONE	Mitochondrial tRNA 3'-end processing →	+0.135	+0.570	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of G2/MI transition of meiotic cell cycle →	+0.134	+0.942	.004	<.001	3	13
OESOPHAGUS	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	+0.122	+0.716	.006	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Carbohydrate homeostasis →	-0.055	-1.097	.003	.001	3	12
BLOOD_Myeloma	Meiotic sister chromatid cohesion →	+0.129	+0.616	.005	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,985 associations by consensus.

tRNA 3'-terminal CCA addition by SS18L2 expression — BONE

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