Across TCGA pan-cancer cohorts, SS18L1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SS18L1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SS18L1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SS18L1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and PDAC are the cancer types where SS18L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.992	0.883	.012	14	view →
GBM	OS	Tertile	All	0.580	0.277	.004	7	view →
PDAC	OS	Median	II,III,IV	0.689	0.335	.018	2	view →
UCEC	OS	Median	All	0.913	0.982	.029	2	view →
CCRCC	DFS	Quartile	All	0.434	0.970	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SS18L1 tumor-vs-normal RNA expression · all SS18L1 data types