SS18

Across TCGA pan-cancer cohorts, SS18 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SS18 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SS18 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SS18 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where SS18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.578	1.000	.005	27	view →
PDAC	DFS	Tertile	All	0.905	0.671	<.001	9	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.881	.032	3	view →
CCRCC	OS	Median	All	0.730	1.000	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SS18–HNSC (DFS)

Open the HNSC breakdown →