SRXN1

Across TCGA patient cohorts, SRXN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,885 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SRXN1-associated proteins across cancer lineages are NFE2L2_S433, PHACTR2, and ST13_S79. Each is linked with SRXN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SRXN1-to-partner and partner-to-SRXN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SRXN1 versus NFE2L2_S433 in LSCC, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SRXN1→partner) and Y-score (partner→SRXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NFE2L2_S433 →	+1.466	+0.999	<.001	<.001	3	4
LSCC	PHACTR2 →	-0.304	-0.498	<.001	<.001	3	3
LSCC	ST13_S79 →	+0.433	+0.368	<.001	.002	3	3
LSCC	TALDO1 →	+0.528	+0.665	<.001	<.001	3	3
LSCC	AKR1C1 →	+2.119	+0.714	<.001	<.001	3	3
LSCC	AKR1C2 →	+1.626	+0.458	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,885 associations by consensus.

SRXN1 vs NFE2L2_S433 — LSCC

Explore this scatter interactively →