SRSF8

Across TCGA pan-cancer cohorts, SRSF8 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SRSF8 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SRSF8 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SRSF8 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BLCA, and ESCA are the cancer types where SRSF8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.436	.011	32	view →
BLCA	DFS	Median	III,IV	0.148	0.574	.004	18	view →
ESCA	DFS	Median	II,III,IV	0.172	0.525	.015	15	view →
SARC	OS	Median	All	0.174	0.730	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SRSF8–UCEC (DFS)

Open the UCEC breakdown →