SRSF8

Across TCGA patient cohorts, SRSF8 mutation is significantly associated with the RNA expression of many other genes, with 5,531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF8-associated genes across cancer lineages are TRDJ2, CYCSP41, and RN7SL447P. Each is linked with SRSF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRSF8-to-partner and partner-to-SRSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDJ2 grouped by SRSF8-low versus SRSF8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF8→partner) and Y-score (partner→SRSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRDJ2 →	+0.633	+2.799	<.001	.001	3	3
LIHC	CYCSP41 →	+0.237	+5.216	<.001	<.001	3	2
CESC	RN7SL447P →	+0.196	+5.201	<.001	.007	3	2
LIHC	LINC00561 →	+0.017	+4.734	<.001	<.001	3	2
BRCA	RNA5SP455 →	+0.317	+8.055	<.001	.007	3	2
BLCA	RN7SL607P →	+0.389	+4.363	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,531 associations by consensus.

TRDJ2 by SRSF8 expression — COAD

Explore this box plot interactively →