SRSF8

Across TCGA patient cohorts, SRSF8 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF8-associated genes across cancer lineages are EGFR_pY1068, GAPDH, and MEK1. Each is linked with SRSF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRSF8-to-partner and partner-to-SRSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SRSF8-low versus SRSF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF8→partner) and Y-score (partner→SRSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.270	-2.700	.001	.005	3	2
UCEC	GAPDH →	+0.528	+2.222	.004	.009	3	2
UCEC	MEK1 →	+0.512	+2.459	<.001	<.001	3	2
UCEC	PARP_cleaved →	-0.223	-2.415	.037	.003	3	2
UCEC	PDCD4 →	-0.532	-1.736	.001	.007	3	2
UCEC	Shc_pY317 →	-0.250	-2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

EGFR_pY1068 by SRSF8 expression — UCEC

Explore this box plot interactively →