SRSF8

Across TCGA cell cohorts, SRSF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,512 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SRSF8-associated GO terms across cancer lineages are Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, Cilium or flagellum-dependent cell motility, and ATF6-mediated unfolded protein response. Each is linked with SRSF8 in more than 7 cancer types. Because this analysis shows association rather than direction, both SRSF8-to-partner and partner-to-SRSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway grouped by SRSF8-low versus SRSF8-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF8→partner) and Y-score (partner→SRSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.099	+0.853	.002	.003	3	8
STOMACH	Cilium or flagellum-dependent cell motility →	-0.093	-1.541	<.001	.002	3	6
KIDNEY	ATF6-mediated unfolded protein response →	+0.088	+0.674	<.001	.001	3	6
LUNG_NSCLC_LUAD	Response to dehydroepiandrosterone →	+0.123	+0.761	<.001	<.001	3	6
STOMACH	Phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.065	+0.817	.002	.008	3	6
BLOOD_Leukemia	Regulation of mRNA processing →	+0.047	+0.744	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,512 associations by consensus.

Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway by SRSF8 expression — LUNG_SCLC

Explore this box plot interactively →