SRSF7

Across TCGA patient cohorts, SRSF7 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF7-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and JNK2. Each is linked with SRSF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF7-to-partner and partner-to-SRSF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SRSF7-low versus SRSF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF7→partner) and Y-score (partner→SRSF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.277	-2.222	.009	.011	3	1
UCEC	INPP4B →	-0.273	-2.999	.046	.035	3	1
UCEC	JNK2 →	+0.179	+3.026	.034	.018	3	1
UCEC	p62 Lck ligand →	+0.514	+2.594	<.001	.006	3	1
UCEC	SF2 →	-0.126	-2.311	.006	.034	3	1
UCEC	Shc_pY317 →	-0.195	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by SRSF7 expression — UCEC

Explore this box plot interactively →